Have questions? Visit https://www.reddit.com/r/SNPedia

rs6330

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 0 more anxious females, less anxious males
(C;T) normal
(T;T) more anxious males, less anxious females
ReferenceGRCh38 38.1/141
Chromosome1
Position115286692
GeneNGF
is asnp
is mentioned by
dbSNPrs6330
dbSNP (old)rs6330
ClinGenrs6330
ebirs6330
HLIrs6330
Exacrs6330
Gnomadrs6330
Varsomers6330
Maprs6330
PheGenIrs6330
Biobankrs6330
1000 genomesrs6330
hgdprs6330
ensemblrs6330
gopubmedrs6330
geneviewrs6330
scholarrs6330
googlers6330
pharmgkbrs6330
gwascentralrs6330
openSNPrs6330
23andMers6330
23andMe allrs6330
SNP Nexus

SNPshotrs6330
SNPdbers6330
MSV3drs6330
GWAS Ctlgrs6330
GMAF0.3058
Max Magnitude0
? (C;C) (C;T) (T;T) 28
rs6330 is a SNP causing a change in an amino acid in the nerve growth factor ([NGF]) gene, and based on this, it is also known as 104C>T or Ala35Val. The more common (C) allele encodes the alanine (Ala).

A study of 337 (age: 39.2 +/- 14.6 years) unrelated subjects of German descent found a significant (p=0.011) gender-dependent effect of this SNP on anxiety related personality traits. rs6330(C;C) females had higher levels of trait anxiety than (C;T) or (T;T) females, while the opposite effect was seen in males.[PMID 18763222]


[PMID 22330829] Possible influence of a non-synonymous polymorphism located in the NGF precursor on susceptibility to late-onset Alzheimer's disease and mild cognitive impairment.


[PMID 17192954] An investigation of the neurotrophic factor genes GDNF, NGF, and NT3 in susceptibility to ADHD.


[PMID 17212826OA-icon.png] TAMGeS: a Three-array Method for Genotyping of SNPs by a dual-colour approach.


[PMID 18520591OA-icon.png] Sequence variants in host cell factor C1 are associated with Meniere's disease.


[PMID 19063739OA-icon.png] Genomic NGFB variation and multiple sclerosis in a case control study.


GET Evidence
NGF-A35V
aa_change Ala35Val
aa_change_short A35V
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.370422
summary



[PMID 23195334] Neurotrophin serum concentrations and polymorphisms of neurotrophins and their receptors in children with asthma


[PMID 23772677] Predicting outcomes following cognitive behaviour therapy in child anxiety disorders: the influence of genetic, demographic and clinical information.


[PMID 25162994] Sex-Specific Association Between Nerve Growth Factor Polymorphism and Cardiac Vagal Modulation


[PMID 26579581] Genetic and environmental predictors of chronic kidney disease in patients with type 2 diabetes and diabetic foot ulcer: a pilot study


[PMID 28413930] Relationship of Genetic Variants With Procedural Pain, Anxiety, and Distress in Children.


ClinVar
Risk Rs6330(T;T)
Alt Rs6330(T;T)
Reference Rs6330(C;C)
Significance Non-pathogenic
Disease Congenital sensory neuropathy with selective loss of small myelinated fibers
Variation info
Gene NGF
CLNDBN Congenital sensory neuropathy with selective loss of small myelinated fibers
Reversed 1
HGVS NC_000001.10:g.115829313G>A
CLNSRC
CLNACC RCV000268865.1,