|(C;C)||more anxious females, less anxious males|
|(T;T)||more anxious males, less anxious females|
A study of 337 (age: 39.2 +/- 14.6 years) unrelated subjects of German descent found a significant (p=0.011) gender-dependent effect of this SNP on anxiety related personality traits. rs6330(C;C) females had higher levels of trait anxiety than (C;T) or (T;T) females, while the opposite effect was seen in males.[PMID 18763222]
[PMID 22330829] Possible influence of a non-synonymous polymorphism located in the NGF precursor on susceptibility to late-onset Alzheimer's disease and mild cognitive impairment.
[PMID 17192954] An investigation of the neurotrophic factor genes GDNF, NGF, and NT3 in susceptibility to ADHD.
[PMID 17212826] TAMGeS: a Three-array Method for Genotyping of SNPs by a dual-colour approach.
[PMID 18520591] Sequence variants in host cell factor C1 are associated with Meniere's disease.
[PMID 19063739] Genomic NGFB variation and multiple sclerosis in a case control study.
|qualified_impact||Insufficiently evaluated not reviewed|
[PMID 23195334] Neurotrophin serum concentrations and polymorphisms of neurotrophins and their receptors in children with asthma
[PMID 23772677] Predicting outcomes following cognitive behaviour therapy in child anxiety disorders: the influence of genetic, demographic and clinical information.
[PMID 25162994] Sex-Specific Association Between Nerve Growth Factor Polymorphism and Cardiac Vagal Modulation
[PMID 26579581] Genetic and environmental predictors of chronic kidney disease in patients with type 2 diabetes and diabetic foot ulcer: a pilot study
[PMID 28413930] Relationship of Genetic Variants With Procedural Pain, Anxiety, and Distress in Children.