|(C;C)||higher risk for RA|
|(C;T)||higher risk for RA|
|(T;T)||2.1||depression, panic, stress response|
|?||(C;C) (C;T) (T;T)||28|
rs6313, also known as T102C, is part of a 4-SNP haplotype in the serotonin 2A receptor gene HTR2A that has been associated with rheumatoid arthritis in a study of 1800 European patients. The risk allele is rs6313(C). The overall risk for the haplotype CTCC of SNPs rs6311-rs1328674-rs6313-rs6314 is 1.68 (CI: 1.20 - 2.34, p = 0.02). [PMID 18006541]
Note: the orientation of rs1328674 in dbSNP is opposite that cited by this publication; therefore, with respect to dbSNP, the haplotype of risk as cited above is CACC rather than CTCC.
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[PMID 17601350] A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.
[PMID 17964050] Lack of association between three serotonin genes and suicidal behavior in Chinese psychiatric patients.
[PMID 18191318] Association study between obsessive-compulsive disorder and serotonergic candidate genes.
[PMID 18196244] Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility.
[PMID 18712714] Genetic variation in the serotonin 2A receptor and suicidal ideation in a sample of 270 Irish high-density schizophrenia families.
[PMID 18797395] Association between the A-1438G polymorphism of the serotonin 2A receptor gene and nonimpulsive suicide attempts.
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[PMID 19184136] Examination of association of genes in the serotonin system to autism.
[PMID 19197363] A genome-wide investigation of SNPs and CNVs in schizophrenia.
[PMID 19379518] Development of a fingerprinting panel using medically relevant polymorphisms.
[PMID 19545856] Sensorimotor gating depends on polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase, but not on neuregulin-1 Arg38Gln genotype: a replication study.
[PMID 19693267] Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene.
[PMID 19742166] Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 variations does not impact alcohol dependence disorder features.
[PMID 19937159] HTR2A is associated with SSRI response in major depressive disorder in a Japanese cohort.
[PMID 20008943] Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study.
[PMID 20403506] Genetic variation in neuroendocrine genes associates with somatic symptoms in the general population: results from the EPIFUND study.
[PMID 20565774] Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.
[PMID 21136126] Temperament profiles, 5-HT2A genotype, and response to treatment with SSRIs in major depression.
[PMID 21162693] Pharmacogenetics and antipsychotics: therapeutic efficacy and side effects prediction.
[PMID 21172166] Pharmacogenetics of antidepressant response.
[PMID 21320838] Variations in 5-HT2A influence spatial cognitive abilities and working memory.
[PMID 21621273] Association of polymorphisms in HTR2A, HTR1A and TPH2 genes with suicide attempts in alcohol dependence: a preliminary report.
[PMID 21930285] The CC genotype in HTR2A T102C polymorphism is associated with behavioral impulsivity in alcohol-dependent patients.
[PMID 22545912] Association of genetic, psychological and behavioral factors with sleep bruxism in a Japanese population.
[PMID 23499153] Genetic polymorphisms of serotonin transporter and receptor 1A could influence success during embryo implantation and maintenance of pregnancy
[PMID 23245538] Association of candidate gene polymorphisms with diastolic blood pressure change in patients treated with duloxetine
[PMID 22735397] Serotonin system gene polymorphisms are associated with impulsivity in a context dependent manner.
[PMID 22751492] Family-based study of HTR2A in suicide attempts: observed gene, gene x environment and parent-of-origin associations.
[PMID 23321485] The CC genotype in the T102C HTR2A polymorphism predicts relapse in individuals after alcohol treatment.
[PMID 23397970] Interpersonal and genetic origins of adult attachment styles: a longitudinal study from infancy to early adulthood.
[PMID 23733030] Pharmacogenetics in major depression: a comprehensive meta-analysis.
[PMID 25174699] Serotonin Receptor Gene (5HT-2A) Polymorphism is Associated with Provoked Vestibulodynia and Comorbid Symptoms of Pain
[PMID 25069264] [Haplotype analysis of serotonin 2A receptor gene polymorphisms and smoking behavior]
[PMID 25758572] 5-Hydroxytryptamine (serotonin) 2A receptor gene polymorphism is associated with schizophrenia
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[PMID 27325396] Dopamine D3 receptor Ser9Gly variant is associated with impulse control disorders in Parkinson's disease patients.
[PMID 29120849] Genetic analysis of impulsive personality traits: Examination of a priori candidates and genome-wide variation.
[PMID 29602729] Sperm count and motility are quantitatively affected by functional polymorphisms of HTR2A, MAOA and SLC18A.
[PMID 30738094] Genetic variants as risk factors for cigarette smoking at an early age and relapse to smoking cessation treatment: A pilot study.
- Is a snp
- In dbSNP
- SNPs on chromosome 13
- Has genotype
- Has population
- On chip 23andMe v1
- On chip 23andMe v2
- On chip 23andMe v3
- On chip 23andMe v4
- On chip 23andMe v5
- On chip Affy GenomeWide 6
- On chip Affy500k
- On chip Ancestry v2c
- On chip Ancestry v2
- On chip FTDNA2
- On chip HumanOmni1Quad
- On chip Illumina Human 1M
- On chip Ancestry v2d