|(C;C)||0||1.6x higher schizophrenia risk|
|(C;T)||1.4x higher schizophrenia risk|
|(T;T)||2||normal schizophrenia risk, learns NoGo faster|
In a study of 300+ Russian patients with schizophrenia, the rs6277(C) allele was associated with higher risk. From a pooled meta-study (total of 4 other reports plus this one) the allelic odds ratio is 1.42 (CI: 1.26-1.61, p<0.00005), and the genotypic odds ratio for the (C;C) genotype was 1.6 (CI: 1.32-1.95, p<0.00005).[PMID 18255274]
Note that rs6275 and rs6277 are only 18bp apart, hence their very tight linkage (r2=1).
gs278 reflects a gene-gene interaction between this SNP and a NR3A SNP, rs10989591, in which older adults with a particular combination of genotypes at these two (independent) loci are reported to exhibit better episodic memory.
23andMe blog people with two As at rs6277(T;T) were better at NoGo learning.
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|qualified_impact||Insufficiently evaluated pharmacogenetic|
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