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rs62256378

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 2 slows rate of cognitive decline in Alzheimer's
Make rs62256378(A;G)
Make rs62256378(G;G)
ReferenceGRCh38 38.1/141
Chromosome3
Position67406609
GeneSUCLG2
is asnp
is mentioned by
dbSNPrs62256378
ClinGenrs62256378
ebirs62256378
HLIrs62256378
Exacrs62256378
Varsomers62256378
Maprs62256378
PheGenIrs62256378
hapmaprs62256378
1000 genomesrs62256378
hgdprs62256378
ensemblrs62256378
gopubmedrs62256378
geneviewrs62256378
scholarrs62256378
googlers62256378
pharmgkbrs62256378
gwascentralrs62256378
openSNPrs62256378
23andMers62256378
23andMe allrs62256378
SNP Nexus

SNPshotrs62256378
SNPdbers62256378
MSV3drs62256378
GWAS Ctlgrs62256378
Max Magnitude2
It was found that the minor allele (A) of rs62256378 in the SUCLG2 gene significantly reduced cognitive decline in AD patients (p=3.1x10-3,beta=0.32) {Beta represents attenuation in cognitive decline as measured in standard deviations of MMSE). This was only significant in epsilon 4 non carriers (p=0.021).

Hum Mol Genet. 2014 Jul 15. pii: ddu372. SUCLG2 identified as both a determinator of CSF Aβ1-42-levels and an attenuator of cognitive decline in Alzheimer's disease [PMID 25027320OA-icon.png]