rs62256378
From SNPedia
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 2 | slows rate of cognitive decline in Alzheimer's |
| Make rs62256378(A;G) |
| Make rs62256378(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 3 |
| Position | 67406609 |
| Gene | SUCLG2 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs62256378 |
| dbSNP (classic) | rs62256378 |
| ClinGen | rs62256378 |
| ebi | rs62256378 |
| HLI | rs62256378 |
| Exac | rs62256378 |
| Gnomad | rs62256378 |
| Varsome | rs62256378 |
| LitVar | rs62256378 |
| Map | rs62256378 |
| PheGenI | rs62256378 |
| Biobank | rs62256378 |
| 1000 genomes | rs62256378 |
| hgdp | rs62256378 |
| ensembl | rs62256378 |
| geneview | rs62256378 |
| scholar | rs62256378 |
| rs62256378 | |
| pharmgkb | rs62256378 |
| gwascentral | rs62256378 |
| openSNP | rs62256378 |
| 23andMe | rs62256378 |
| SNPshot | rs62256378 |
| SNPdbe | rs62256378 |
| MSV3d | rs62256378 |
| GWAS Ctlg | rs62256378 |
| Max Magnitude | 2 |
It was found that the minor allele (A) of rs62256378 in the SUCLG2 gene significantly reduced cognitive decline in AD patients (p=3.1x10-3,beta=0.32) {Beta represents attenuation in cognitive decline as measured in standard deviations of MMSE). This was only significant in epsilon 4 non carriers (p=0.021).
Hum Mol Genet. 2014 Jul 15. pii: ddu372.
SUCLG2 identified as both a determinator of CSF Aβ1-42-levels and an attenuator of cognitive decline in Alzheimer's disease
[PMID 25027320
]
