rs61751103
From SNPedia
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | common |
| (C;G) | 4 | rare mutation increasing risk for late-onset Alzheimer's disease |
| Make rs61751103(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 15 |
| Position | 58665172 |
| Gene | ADAM10 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs61751103 |
| dbSNP (classic) | rs61751103 |
| ClinGen | rs61751103 |
| ebi | rs61751103 |
| HLI | rs61751103 |
| Exac | rs61751103 |
| Gnomad | rs61751103 |
| Varsome | rs61751103 |
| LitVar | rs61751103 |
| Map | rs61751103 |
| PheGenI | rs61751103 |
| Biobank | rs61751103 |
| 1000 genomes | rs61751103 |
| hgdp | rs61751103 |
| ensembl | rs61751103 |
| geneview | rs61751103 |
| scholar | rs61751103 |
| rs61751103 | |
| pharmgkb | rs61751103 |
| gwascentral | rs61751103 |
| openSNP | rs61751103 |
| 23andMe | rs61751103 |
| SNPshot | rs61751103 |
| SNPdbe | rs61751103 |
| MSV3d | rs61751103 |
| GWAS Ctlg | rs61751103 |
| Max Magnitude | 4 |
rs61751103, also known as Q170H or Gln170His, is a SNP in the ADAM metallopeptidase domain 10 ADAM10 gene. The common allele is rs61751103(C) (in the FWD direction, not in the mRNA), encoding the Gln.
[PMID 19608551
] The rs61751103(G) allele was found in 11 of 16 individuals affected by Alzheimer's disease (average onset age 69.5 years) from seven late-onset AD families. This mutation was also found in at least one unaffected subject, implying incomplete penetrance.
This SNP is referred to as i6006818 by 23andMe.
