rs61729907 is a SNP in the OR7D4 olfactory receptor gene. This SNP causes a change at amino acid 88 of the OR7D4 protein from Arginine to Tryptophan (R88W or Arg88Trp).
[PMID 17873857] Genetic variation in a human odorant receptor alters odour perception.
A common variant of the receptor OR7D4, OR7D4 WM contains two non-synonymous single nucleotide polymorphisms (SNPs), resulting in two amino acid substitutions (R88W, T133M; hence 'RT') that severely impair function in vitro. Human subjects with RT/WM or WM/WM genotypes as a group were less sensitive to androstenone and androstadienone and found both odours less unpleasant than the RT/RT group.
[PMID 22362865] A genome-wide study on the perception of the odorants androstenone and galaxolide.
Replicated the previously reported association between perception of androstenone and OR7D4 and revealed that individuals with homozygous mutations in rs61729907 impaired androstenone perception