|?|| (A;A) (A;G) (G;G) ||28|
, located in the first exon of the androgen receptor AR
gene located on the X chromosome, is highly indicative of the ability to develop male pattern baldness
. The risk allele is (G). However, although it appears to be necessary for baldness
to develop, other (as yet unknown) variations must also be present for baldness
to actually occur. [PMID 11231320
], [PMID 17256155
Since this SNP is on the X chromosome, and affects a trait primarily seen only in males, a single allele is shown as representing the individual's genotype. However, baldness may also occur in females, presumably only in females homozygous for rs6152(G;G) and also harboring the (as yet unknown) additional variations required for baldness.
Note: The colorful and informative Figure 1 in [PMID 17256155] shows the probability of varying degrees of baldness as men age depending on whether they are rs6152(A) or rs6152(G).
Note: A subsequent study has found that rs1160312 may be an important additional variant acting in conjunction with rs6152 to influence baldness.
[PMID 15902657] baldness
- lowest P value of 2.1×10-12 for rs10521339
- family based rs938059 shows the lowest P value (4.03×10-6) (table 3)
- rs6152 (P=6.66×10-10)
] Androgen receptor gene polymorphisms and risk for androgenetic alopecia: a meta-analysis
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[PMID 16987421] A comprehensive analysis of the androgen receptor gene and risk of breast cancer: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3).
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[PMID 20450840] Association of AR rs6152G/A gene polymorphism with susceptibility to polycystic ovary syndrome in Chinese women.
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