|?|| (A;A) (A;G) (G;G) ||28|
( G(-1211)A ) is a SNP within GNAS
(GNAS complex locus - encoding the Gs alpha subunit).
[PMID 18192900] among a group of 110 individuals participating in a randomized placebo-controlled weight loss trial (and under a low calorie diet)...
- those with GG genotypes lost significantly more weight compared to A allele carriers
- sibutramine was effective only in A allele carriers for weight loss, however, carriers for two Gs showed the strongest increases in resting heart rate and systolic blood pressure
[PMID 19593725] Association of maternally inherited GNAS alleles with African-American male birth weight.
[PMID 23065660] GNAS A-1121G variant is associated with improved diastolic dysfunction in response to exercise training in heart failure patients.