|| common on affy axiom data
|?|| (A;A) (A;G) (G;G) ||28|
| Disease Association
|| High concentrations of PAI-1 have been associated with thrombophilia (MIM:188050); an autosomal dominant disorder in which affected individuals are prone to develop serious spontaneous thrombosis.
] Plasminogen-activator inhibitor-1 polymorphisms are associated with obesity and fat distribution in the Quebec Family Study: evidence of interactions with menopause.
[PMID 17656673] Association of plasminogen activator inhibitor (PAI)-1 (SERPINE1) SNPs with myocardial infarction, plasma PAI-1, and metabolic parameters: the HIFMECH study.
[PMID 17761618] 4G/5G plasminogen activator inhibitor-1 polymorphisms and haplotypes are associated with pneumonia.
[PMID 18285546] A PAI-1 (SERPINE1) polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group.
[PMID 18794724] Plasminogen activator inhibitor-1 gene is associated with major depression and antidepressant treatment response.
[PMID 19360663] Genetic evidence implicating multiple genes in the MET receptor tyrosine kinase pathway in autism spectrum disorder.
[PMID 20127289] Contribution of genetic and metabolic syndrome to omental adipose tissue PAI-1 gene mRNA and plasma levels in obesity.
|| not reviewed
|| Insufficiently evaluated not reviewed
[PMID 24355042] Association of five common polymorphisms in the plasminogen activator inhibitor-1 gene with primary ovarian insufficiency