|?|| (A;A) (A;G) (G;G) ||28|
is a SNP in the cyclin D1 CCND1
gene. It is also known as Pro241Pro. The associated genotypes are characterized in terms of their enzymatic activity as High for (A;A), Medium (A;G), and Low (G;G).
In a study of 2 populations of breast cancer patients (2,000+ patients), increased risk was associated with rs603965(A;A) genotypes in both the Ontario [odds ratio 2.22, CI: 1.49-3.28] and Finland [OR 1.73, CI: 1.08-2.78] populations.[PMID 18194538]
[PMID 24264314] Association between CCND1 and XPC polymorphisms and bladder cancer risk: a meta-analysis based on 15 case-control studies
[PMID 27156331] SNP rs1059234 in CDKN1A Gene Correlates with Prognosis in Resected Gastric Adenocarcinoma.
[PMID 28380465] Impact of interaction between the G870A and EFEMP1 gene polymorphism on glioma risk in Chinese Han population.