news The effectiveness of 17 alpha-hydroxyprogesterone caproate for prevention of recurrent preterm birth is influenced by SNPs.
- rs471767 homozygous for the major allele treatment significantly reduced the rate of preterm birth.
- rs578029 who had a least one copy of the major allele, treatment significantly reduced in preterm birth
- a least one copy of the minor allele of rs503362 had a significant reduction with treatment
- with at least one copy of the minor allele of rs666553 had a significant reduction in very preterm birth
[PMID 21600550] Progesterone receptor polymorphisms and clinical response to 17-alpha-hydroxyprogesterone caproate
[PMID 20308837] Progesterone receptor genotype, family history, and spontaneous preterm birth.