|(C;T)||increased risk for hypertension|
|(T;T)||increased risk for hypertension|
rs5051 is also known as "A-6G". For more details, see rs699.
rs5051(T;T) homozygotes have been reported to be at increased risk for Crohn's disease, as based on one cohort of ~350 Australian patients. The odds ratio was 2.38 (CI: 1.32-4.32, p=0.007). The authors suggest that association of an AGT SNP with Crohn's disease supports a potential role for angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists in the treatment of Crohn's disease.[PMID 17047091]
[PMID 22508051] Renin-Angiotensin-aldosterone system gene polymorphisms and coronary artery disease: detection of gene-gene and gene-environment interactions
[PMID 16286570] A population association study of angiotensinogen polymorphisms and haplotypes with left ventricular phenotypes.
[PMID 18076107] Confronting complexity in late-onset Alzheimer disease: application of two-stage analysis approach addressing heterogeneity and epistasis.
[PMID 19105203] An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3.
[PMID 20808897] Disease-associated mutations that alter the RNA structural ensemble.
[PMID 22388798] Gene panels to help identify subgroups at high and low risk of coronary heart disease among those randomized to antihypertensive treatment: the GenHAT study.
[PMID 23716723] The Relationship Between Angiotensinogen Gene Polymorphisms and Essential Hypertension in a Northern Han Chinese Population
[PMID 21859746] Genetic and BMI risks for predicting blood pressure in three generations of West African Dogon women.
[PMID 26142106] Epistatic interaction between common AGT G(-6)A (rs5051) and AGTR1 A1166C (rs5186) variants contributes to variation in kidney size at birth
[PMID 24722536] Relationship of renin-angiotensin-aldosterone system polymorphisms and phenotypes to mortality in Chinese coronary atherosclerosis patients