||Normal risk for meningioma
||1.61x increased risk for meningioma
||2.33x increased risk for meningioma
rs4968451, which is in a breast cancer susceptibility gene, was associated with increased risk of meningioma, a common form of brain tumor, in a combination of five studies totaling 631 European case patients as well 637 European control subjects.
"Meningioma risks associated with hetero- and homozygosity for the minor allele of were 1.61 (95% CI = 1.26 to 2.06) and 2.33 (95% CI = 1.25 to 4.34), respectively, and were thus compatible with a multiplicative model of action." The risk allele and minor allele is rs4968451(C). Around 30% of Europeans carry one of risk genotypes, i.e. rs4968451(A;C) or (C;C); and perhaps 16% of meningiomas might be associated with this SNP.[PMID 18270339]
[PMID 18505952] Genetic susceptibility to cancer: the role of polymorphisms in candidate genes.
[PMID 19276285] Associations between single nucleotide polymorphisms in double-stranded DNA repair pathway genes and familial breast cancer.
[PMID 29581016] CASP8, XRCC1, WRN, NF2 and BRIP1 polymorphisms analysis reveals their genetic susceptibility for meningioma risk and the association with tumor-related phenotype in Chinese population.