|(C;C)||1.9||Normal (higher) risk of Asthma.|
|(C;G)||2||Half the risk (maybe) of Asthma.|
|(G;C)||2||Half the risk (maybe) of Asthma.|
|(G;G)||2||Half the risk (maybe) of Asthma.|
[PMID 18767121] An attempt to repeat the association between rs4950928 and risk for schizophrenia in an ethnically identical population (Japanese) as well as a new population (Han Chinese) failed to show any significant association.
|95% CI||NR) ng/ml decreas|
[PMID 19421404] Variation in CHI3LI in relation to type 2 diabetes and related quantitative traits[PMID 20051317] The chitinase 3-like 1 gene and schizophrenia: Evidence from a multi-center case-control study and meta-analysis [PMID 21714862] Promoter polymorphisms in the chitinase 3-like 1 gene influence the serum concentration of YKL-40 in Danish patients with rheumatoid arthritis and in healthy subjects
[PMID 22103814] YKL-40 genetic polymorphisms and the risk of liver disease progression in patients with advanced fibrosis due to chronic hepatitis C
[PMID 22366530] A promoter variant in the Chitinase 3-Like 1 gene is associated with serum YKL-40 level and personality trait
[PMID 22183936] Chitinase 3-like 1 plasma levels are increased in patients with progressive forms of multiple sclerosis.
[PMID 19264973] Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.
[PMID 19336781] Molecular differentiation of schizoaffective disorder from schizophrenia using BDNF haplotypes.
[PMID 20300754] Lack of evidence for association of two functional SNPs of CHI3L1 gene (HC-gp39) with rheumatoid arthritis.
[PMID 21257319] Genetic polymorphisms in chitinase 3-like 1 (CHI3L1) are associated with circulating YKL-40 levels, but not with angiographic coronary artery disease in a Chinese population.
[PMID 21530869] The CHI3L1 rs4950928 polymorphism is associated with asthma-related hospital admissions in children and young adults.
[PMID 23190377] Association of CHI3L1 in African-Americans with Prior History of Asthma Exacerbations and Stress
[PMID 23279705] A polymorphism associated with increased levels of YKL-40 and the risk of early onset of lone atrial fibrillation
[PMID 22989351] YKL-40-gene polymorphism affects acute cellular rejection and fibrosis progression after transplantation for hepatitis C virus-induced liver disease.
[PMID 23628340] The chitinase-like protein YKL-40: a possible biomarker of inflammation and airway remodeling in severe pediatric asthma.
[PMID 25203433] Correlation of Chitinase 3-Like 1 Single Nucleotide Polymorphisms and Haplotypes with Uterine Cervical Cancer in Taiwanese Women
[PMID 25486056] Circulating YKL-40 level, but not CHI3L1 gene variants, is associated with atherosclerosis-related quantitative traits and the risk of peripheral artery disease
[PMID 25592985] Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40
[PMID 26672955] YKL-40 and genetic status of CHI3L1 in a large group of asthmatics.
|Risk||rs4950928(A;A) Rs4950928(C;C) rs4950928(T;T)|
|Alt||rs4950928(A;A) Rs4950928(C;C) rs4950928(T;T)|
|CLNDBN||Asthma-related traits, susceptibility to, 7|
|CLNSRC||OMIM Allelic Variant|