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rs4947296

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 2 Increased (2.5x) risk for Graves' disease
(C;T) 1.7 Slightly (1.7x) increased risk for Graves' disease
(T;T) 0 common on affy axiom data
ReferenceGRCh38 38.1/141
Chromosome6
Position31090401
is asnp
is mentioned by
dbSNPrs4947296
ClinGenrs4947296
ebirs4947296
HLIrs4947296
Exacrs4947296
Varsomers4947296
Maprs4947296
PheGenIrs4947296
hapmaprs4947296
1000 genomesrs4947296
hgdprs4947296
ensemblrs4947296
gopubmedrs4947296
geneviewrs4947296
scholarrs4947296
googlers4947296
pharmgkbrs4947296
gwascentralrs4947296
openSNPrs4947296
23andMers4947296
23andMe allrs4947296
SNP Nexus

SNPshotrs4947296
SNPdbers4947296
MSV3drs4947296
GWAS Ctlgrs4947296
GMAF0.09504
Max Magnitude2

rs4947296 is considered to be a SNP in the MUC21 gene, located upstream of the HLA locus on chromosome 6.

A 2011 study of ~5,000 patients with Graves' disease found an association with rs4947296(C); the odds ratio was 1.77 (CI: 1.65-1.91, p = 3.5 x 10e-51).[PMID 21847180OA-icon.png]

? (C;C) (C;T) (T;T) 28
GWAS snp
PMID [PMID 21841780]
Trait
Title A genome-wide association study identifies two new risk loci for Graves' disease.
Risk Allele C
P-val 4E-51
Odds Ratio 1.7700 [1.65-1.91]
GWAS snp
PMID [PMID 23001997]
Trait Behcet's disease
Title Identification of a susceptibility locus in STAT4 for Behçet's disease in Han Chinese in a genome-wide association study.
Risk Allele
P-val 1E-11
Odds Ratio 2.57 [1.96-3.37]