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rs4845618

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) normal
(G;T) 1.5 1.7x increased melanoma risk
(T;T) normal?
ReferenceGRCh38 38.1/141
Chromosome1
Position154427539
GeneIL6R
is asnp
is mentioned by
dbSNPrs4845618
dbSNP (old)rs4845618
ClinGenrs4845618
ebirs4845618
HLIrs4845618
Exacrs4845618
Gnomadrs4845618
Varsomers4845618
Maprs4845618
PheGenIrs4845618
Biobankrs4845618
1000 genomesrs4845618
hgdprs4845618
ensemblrs4845618
gopubmedrs4845618
geneviewrs4845618
scholarrs4845618
googlers4845618
pharmgkbrs4845618
gwascentralrs4845618
openSNPrs4845618
23andMers4845618
23andMe allrs4845618
SNP Nexus

SNPshotrs4845618
SNPdbers4845618
MSV3drs4845618
GWAS Ctlgrs4845618
GMAF0.4761
Max Magnitude1.5
? (G;G) (G;T) (T;T) 28

A study of 219 female melanoma patients and an equal number of controls concluded that 4 linked SNPs within the IL6R gene were associated with increased melanoma risk, but only when heterozygous. The odds ratio associated with the minor allele of this SNP, rs4845618, was 1.72 (CI: 1.04-2.84). The 4 linked SNPs from identified in this study are: rs6684439, rs4845618, rs4845622, and rs8192284.[PMID 18781131OA-icon.png]


[PMID 17357077OA-icon.png] Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels.


[PMID 18276608] Interleukin-6 (IL-6) and receptor (IL6-R) gene haplotypes associate with amniotic fluid protein concentrations in preterm birth.


[PMID 18787421OA-icon.png] Genetic contributions to disparities in preterm birth.


[PMID 18852330OA-icon.png] Interleukin-6 receptor gene, plasma C-reactive protein, and diabetes risk in women.


[PMID 19249341OA-icon.png] Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults.