A study of 219 female melanoma patients and an equal number of controls concluded that 4 linked SNPs within the IL6R gene were associated with increased melanoma risk, but only when heterozygous. The odds ratio associated with the minor allele of this SNP, rs4845618, was 1.72 (CI: 1.04-2.84). The 4 linked SNPs from identified in this study are: rs6684439, rs4845618, rs4845622, and rs8192284.[PMID 18781131
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[PMID 17357077] Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels.
[PMID 18276608] Interleukin-6 (IL-6) and receptor (IL6-R) gene haplotypes associate with amniotic fluid protein concentrations in preterm birth.
[PMID 18787421] Genetic contributions to disparities in preterm birth.
[PMID 18852330] Interleukin-6 receptor gene, plasma C-reactive protein, and diabetes risk in women.
[PMID 19249341] Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults.
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