|(C;T)||2||1.23x risk for colorectal cancer|
|(T;T)||2||1.70x risk for colorectal cancer|
|?||(C;C) (C;T) (T;T)||28|
A study of 7000+ UK patients with colorectal cancer identified two SNPs that increase disease risk, one of which is rs4779584. Inheriting the rs4779584(T) risk allele is estimated to increase overall risk odds by 1.26x (CI: 1.19-1.34, p=4x10e-14). When analyzing data between genotypes, the odds ratios reported for heterozygotes was 1.23x (CI:1.13-1.33), and for rs4779584(T;T) homozygotes, 1.70 (CI: 1.41-2.04).[PMID 18084292]
Inheriting the risk variant at both SNP loci (i.e. rs4779584 and rs6983267) is estimated to increase the overall risk of developing colorectal cancer about 3 fold. The authors of this study are quoted as saying that "the lifetime risk [of bowel cancer] is about 5% in the UK so it's going up to 7% or so if you've got both bad copies of a variant." nature
This SNP has also been associated with increased colorectal cancer risk in a French study of 1,000+ patients.10.1038/ejhg.2015.72
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|Odds Ratio||1.23 [1.14-1.34]|
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|Odds Ratio||1.1800 [1.11-1.24]|
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|Odds Ratio||1.12 [1.08-1.19]|
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- Is a snp
- In dbSNP
- SNPs on chromosome 15
- Has genotype
- Has population
- Uses doi
- Uses omim
- On chip 23andMe v1
- On chip 23andMe v2
- On chip 23andMe v3
- On chip 23andMe v4
- On chip 23andMe v5
- On chip Affy GenomeWide 6
- On chip Ancestry v2c
- On chip Ancestry v2d
- On chip Ancestry v2
- On chip HumanOmni1Quad
- On chip Illumina Human 1M