|(C;T)||1.9x risk for pre-eclampsia|
|(T;T)||>1.9x risk for pre-eclampsia|
Note that rs4762 is commonly referred to in the literature as "T174M" or "Thr174Met"; however, databases now indicate that the amino acid that varies is #207 (not 174), as the protein is currently numbered.
|Disease Association||Defects in AGT are associated with susceptibility to essential hypertension (MIM:145500). Hypertension also occurs in 5-7% of all pregnancies where it is a leading cause of maternal, fetal and neonatal morbidity and mortality. Among pregnancy- induced hypertension cases, severe preeclampsia (MIM:189800) is characterized by the development of hypertension and proteinuria after the 20th week of pregnancy and is the most distinctive, life-threatening form.|
[PMID 18653189] Interaction of gender, hypertension, and the angiotensinogen gene haplotypes on the risk of coronary artery disease in a large angiographic cohort
[PMID 21988197] Angiotensinogen gene haplotype is associated with the prevalence of Japanese non-alcoholic steatohepatitis
[PMID 22508051] Renin-Angiotensin-aldosterone system gene polymorphisms and coronary artery disease: detection of gene-gene and gene-environment interactions
[PMID 18196181] Correction of population stratification in large multi-ethnic association studies.
[PMID 18279468] Ten renin-angiotensin system-related gene polymorphisms in maximally treated Canadian Caucasian patients with heart failure.
[PMID 18637188] RAS gene polymorphisms, classical risk factors and the advent of coronary artery disease in the Portuguese population.
[PMID 19105203] An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3.
[PMID 19587357] A systematic meta-analysis of genetic association studies for diabetic retinopathy.
|qualified_impact||Insufficiently evaluated not reviewed|
[PMID 23594830] Angiotensinogen Polymorphisms and Post-Transplantation Diabetes Mellitus in Korean Renal Transplant Subjects
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[PMID 28271690] Genetic Variation in the Renin-Angiotensin System and Diabetic Nephropathy in the Tunisian Population.
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