||Slightly (~1.6x) increased risk for neuroblastoma
||very slightly (~1.3x) increased risk for neuroblastoma
SNPs clustered in one region of chromosome 6p22 have been linked to increased risk for the exceedingly rare childhood cancer known as neuroblastoma. A study involving 720 patients determined that rs4712653(C;C) genotypes had increased likelihood of neuroblastoma development (odds ratio 1.35, CI: 1.24 to 1.46, p= 5.5 x 10e13). At-risk homozygotes diagnosed with neuroblastoma had, on average, more malignant clinical presentation, more aggressive disease, and poorer long-term survival.[PMID 18463370]
For more information on this cluster of SNPs, see rs6939340.
||Integrative genomics identifies LMO1 as a neuroblastoma oncogene
[PMID 19412175] Common variations in BARD1 influence susceptibility to high-risk neuroblastoma.