rs4675690 is in close proximity to CREB1, and adjacent to LOC151194.
g2b2mh blog [PMID 18678793] individuals with the TT genotype at rs4675690 (C/T) showed less disgust, but not happiness, desire or fear.
[PMID 17548750] T allele associated with increased chance of suicide (OR = 2.3, 95% CI 1.3-2.9, TT homozygotes vs CC homozygotes?) during the first 30 days (p > 0.05 after the first month) of citalopram treatment, in a study of 1447 citalopram users (male only subgroup, 539 in total). Two haplotypes (see below) also showed significant association with suicidality in the male subgroup.
- rs2709376(C),rs2253206(A),rs7569963(A),rs7594560(T),rs4675690(C) - common haplotype, reduced chance of suicide in males, p = 0.004
- rs2709376(C),rs2253206(A),rs7569963(G),rs7594560(T),rs4675690(T) - increased chance of suicide in males, p = 0.009
[PMID 17300755] strongly associated with anger expression in male MDD patients
[PMID 21807415] Early influence of the rs4675690 on the neural substrates of sadness
[PMID 22293360] Genotype distributions and allele frequencies of possible major depressive disorder-associated single nucleotide polymorphisms, cyclic adenosine monophosphate response element binding protein 1 rs4675690 and Piccolo rs2522833, in a Japanese population
[PMID 20643483] A preliminary investigation of the influence of CREB1 gene on treatment resistance in major depression.
[PMID 22574704] CREB1 modulates the influence of childhood sexual abuse on adult's anger traits.