Rs4504469, a nonsynonymous SNP in exon 4 of the KIAA0319 gene, is in a region that crops up in several independent studies as likely to associated with dyslexia. The risk allele in the Caucasian populations studied is (T).
The odds ratio in a study of case:control study of ~400 Caucasians associated with rs4504469(T) is 1.51 (CI: 1.17â€“1.95, p = 0.002). [PMID 15717286]
[PMID 15514892] A 77-kilobase region of chromosome 6p22.2 is associated with dyslexia in families from the United Kingdom and from the United States.
[PMID 16385449] Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia.
[PMID 19325871] A common variant associated with dyslexia reduces expression of the KIAA0319 gene.
[PMID 19997522] Convergent genetic linkage and associations to language, speech and reading measures in families of probands with Specific Language Impairment.
[PMID 23677054] Analysis of genetic variants of dyslexia candidate genes KIAA0319 and DCDC2 in Indian population