rs449647

Orientation

minus

Stabilized

minus

Geno	Mag	Summary
(A;A)	2	lower levels of ApoE
(A;T)	1.2	Possibly lower levels of ApoE
(T;T)	1.5	Normal levels of ApoE

Reference

GRCh38 38.1/142

Chromosome

19

Position

44905307

Gene

APOE

is a	snp
is	mentioned by
dbSNP	rs449647
dbSNP (classic)	rs449647
ClinGen	rs449647
ebi	rs449647
HLI	rs449647
Exac	rs449647
Gnomad	rs449647
Varsome	rs449647
LitVar	rs449647
Map	rs449647
PheGenI	rs449647
Biobank	rs449647
1000 genomes	rs449647
hgdp	rs449647
ensembl	rs449647
geneview	rs449647
scholar	rs449647
google	rs449647
pharmgkb	rs449647
gwascentral	rs449647
openSNP	rs449647
23andMe	rs449647
SNPshot	rs449647
SNPdbe	rs449647
MSV3d	rs449647
GWAS Ctlg	rs449647

GMAF

0.1758

Max Magnitude

2

[PMID 19172988] Significant Alzheimer's disease associations with were found for rs449647(A;A) and rs405509(G;G) genotypes (positive), and rs449647(A;T) and rs405509(T;T)

[PMID 21263195] An APOE Haplotype Associated with Decreased ?4 Expression Increases the Risk of Late Onset Alzheimer's Disease

[PMID 22028770] APOE Genotype-Function Relationship: Evidence of -491 A/T Promoter Polymorphism Modifying Transcription Control but Not Type 2 Diabetes Risk

[PMID 17434289] Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: patterns of linkage disequilibrium and disease/marker association.

[PMID 18161859] Does APOE explain the linkage of Alzheimer's disease to chromosome 19q13?

[PMID 25085564] Influence of multiple