|(C;C)||2||1.35x increased risk for colorectal cancer|
|(C;T)||1.5||1.10x increased risk for colorectal cancer|
|(T;T)||1||Normal risk for colorectal cancer|
rs4464148 is one of 3 SNPs in the SMAD7 gene associated with risk for colorectal cancer, based on a large study (7,400+ cases) conducted in the UK. The odds ratios show an increased risk for the minor rs4464148(C) allele; the OR for (C;C) homozygotes is 1.35 (CI: 1.2-1.51), and for (C;T) heterozygotes 1.10 (CI: 1.09-1.21), overall p=7x10-8.[PMID 17934461]
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