||>1.5x increased testicular cancer risk for men
||1.5x increased testicular cancer risk for men
||Normal risk of testicular cancer.
Testicular germ cell tumor risk I("TGCT"; i.e. testicular cancer risk) was increased 40% per copy of the major (T) allele at rs4324715 and rs6897876 (OR = 1.37, CI: 1.14–1.64; OR = 1.39, CI: 1.16–1.66, respectively), based on a genome-wide scan of 277 primarily Caucasian TGCT cases and 919 controls. Men who have two copies of the common version of the sprouty 4 SPRY4 gene have a 1.5-fold higher risk of testicular cancer than men who have two copies of the less common or minor version of the gene. [doi|10.1038/ng.393]
[PMID 19483682] Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer.
[PMID 22072546] Associations between variants in KITLG, SPRY4, BAK1, and DMRT1 and pediatric germ cell tumors.