| Geno
|
Mag
|
Summary
|
| (A;A)
|
1.5
|
2.3x risk for lupus
|
| (A;G)
|
1.2
|
2.0x risk for lupus
|
| (G;G)
|
0
|
average
|
| ? | (A;A) (A;G) (G;G) | 28 |
|---|
 |
, a SNP in an intron of the
SKIV2L gene in the MHC class III region, has been associated with
lupus in a large study of UK patients. In dbSNP orientation, the risk allele is
rs419788(A), and the risk is dose-dependent (i.e.
rs419788(A;A) individuals are at higher risk than
rs419788(A;G) individuals]. The reported odds ratio is 2.0 (CI: 1.6 - 2.6, permuted p < 0.0001). [
PMID 17997607
]
[PMID 19851445] High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
]
