||carrier of one CYP3A5*7 allele
||Miscall in 23andMe v4 data; otherwise, CYP3A5*7 homozygote; nonexpressor for CYP3A5
rs41303343, also known as 27131_27132insT, is a SNP in the CYP3A5 gene.
The rs41303343(T) allele defines the CYP3A5*7 variant, which is nonfunctional and has the highest prevalence in those of African descent (where ~8% of the population are carriers).
Note that the scientific literature (and PharmGKB, among other sources) often incorrectly reports a different SNP (rs76293380) as defining the CYP3A5*7 allele. That SNP is actually defined as a deletion, not as in insertion, at the same position as rs41303343.
In 23andMe v4-based data, this SNP is reported nearly 100% of the time as II (which would be equivalent to TT), and this is clearly incorrect. In 23andMe v5-based data, this SNP is normally missing.
[PMID 21806386] Pharmacogenetics of calcineurin inhibitors in Brazilian renal transplant patients
[PMID 24427273] Global Pharmacogenomics: Distribution of CYP3A5 Polymorphisms and Phenotypes in the Brazilian Population