|| common in clinvar
|?|| (A;A) (A;G) (G;G) ||28|
This SNP influences appearance and is located in the TPCN2 gene. A study [PMID 18488028] of 5130 Icelanders (with further followup in another 2116 Icelanders and 1214 Dutch individuals) found significant association between a group of SNPs within the TPCN2 gene.All of the discovered difference between blonde and brown hair could be explained by genotypes with rs3829241 and Rs35264875. The A allele was significantly associated with blonde versus brown hair with a P-value 6.2e-16
Summaried in gnxp
|Desc||SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 10; SHEP10|
|| Low clinical importance, Uncertain benign
|| Pigmentation allele.
[PMID 26918892] Genetic Variants of TPCN2 Associated with Type 2 Diabetes Risk in the Chinese Population.