|?|| (A;A) (A;C) (C;C) ||28|
and a 5 bp insertion-deletion linked multiple sclerosis
in three populations
[PMID 18288123] Associated with systemic lupus erythematosus (SLE) in African Americans.
|Desc||INTERFERON REGULATORY FACTOR 5; IRF5|
] Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.
[PMID 17189288] Association of IRF5 in UK SLE families identifies a variant involved in polyadenylation.
[PMID 18668568] Association of the IRF5 risk haplotype with high serum interferon-alpha activity in systemic lupus erythematosus patients.
[PMID 19109131] Cutting edge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-alpha in lupus patients in vivo.
[PMID 19956648] Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases.
[PMID 20479942] Genetic risk factors in lupus nephritis and IgA nephropathy--no support of an overlap.
[PMID 20603721] Genome-wide association filtering using a highly locus-specific transmission/disequilibrium test.
[PMID 20861862] Validation of IRF5 as multiple sclerosis risk gene: putative role in interferon beta therapy and human herpes virus-6 infection.
[PMID 23971939] IRF5, but not TLR4, DEFEB1, or VDR, is associated with the risk of ulcerative colitis in a Han Chinese population
|| [PMID 21156761]
|| Rheumatoid arthritis
|| A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.
| Risk Allele
| Odds Ratio
|| 1.44 [1.25-1.66]
[PMID 25564941] Association between genetic polymorphisms in Interferon Regulatory Factor 5 (IRF5) gene and Malaysian patients with Crohn's disease