Variant in the C13orf31 region associated with increased susceptibility to leprosy, according to the 23andMe blog 23andMe blog. The risk allele is G, and the odds ratio is 1.68.
Other genes associated with both Crohn's disease and leprosy include NOD2 and TNFSF15, according to 23andMe's blog.
| GWAS snp
|
| PMID
|
[PMID 20018961]
|
| Trait
|
Leprosy
|
| Title
|
Genomewide Association Study of Leprosy
|
| Risk Allele
|
G
|
| P-val
|
4E-54
|
| Odds Ratio
|
1.68 [1.57-1.80]
|
[PMID 25642632] Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.
[PMID 21304977
] An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
[PMID 19068216] Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.
Leprosy Susceptibility
| GWAS snp
|
| PMID
|
[PMID 23128233]
|
| Trait
|
Crohn's disease
|
| Title
|
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
| Risk Allele
|
G
|
| P-val
|
2E-21
|
| Odds Ratio
|
1.16 [1.112-1.199]
|
| GWAS snp
|
| PMID
|
[PMID 21102463]
|
| Trait
|
Crohn's disease
|
| Title
|
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
| Risk Allele
|
G
|
| P-val
|
1E-10
|
| Odds Ratio
|
1.17 [1.12-1.23]
|
[PMID 23974994] Replication Study of Ulcerative Colitis Risk Loci in a Lithuanian-Latvian Case-Control Sample
]
