|(T;T)||increased risk of obesity|
Within the FTO gene, many SNPs appear to be co-inherited. The SNP showing the strongest association with body weight (i.e. body mass index, BMI) is not rs3751812, although this SNP is one of the co-inherited SNPs in the FTO gene region. For more information, refer to the FTO gene or the most studied FTO SNPs, rs9930506 or rs9939609. [PMID 17658951]
[PMID 18335027] implicated for african americans
[PMID 19322589] Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study
[PMID 20430937] Fine-mapping of the association with obesity at the FTO locus in African-derived populations
[PMID 21443588] Association between the FTO gene and overweight in Japanese children and adolescents
[PMID 18379722] Variations in the FTO gene are associated with severe obesity in the Japanese.
[PMID 18647953] Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test.
[PMID 19060910] Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
[PMID 19074959] ATOM: a powerful gene-based association test by combining optimally weighted markers.
[PMID 19265514] FTO gene variation and measures of body mass in an African population.
[PMID 19478790] The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI.
[PMID 20381893] The genetics of obesity: FTO leads the way.
[PMID 20404173] A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly.
[PMID 20442772] Common SNPs in FTO gene are associated with obesity related anthropometric traits in an island population from the eastern Adriatic coast of Croatia.
[PMID 20502638] Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study.
[PMID 20694148] A genome-wide association study of the metabolic syndrome in Indian Asian men.
[PMID 21102551] Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort.
[PMID 23628854] FTO predicts weight regain in the Look AHEAD clinical trial
[PMID 23933215] Body Mass Index, but not FTO genotype or Major Depressive Disorder, influences brain structure
[PMID 23408508] Obesity-susceptibility loci and the tails of the pediatric BMI distribution
[PMID 21799482] Common genetic variants and central adiposity among Asian-Indians.
[PMID 24911064] Association of FTO Polymorphisms with Obesity and Metabolic Parameters in Han Chinese Adolescents
[PMID 26726774] Gender-Dependent Association of FTO Polymorphisms with Body Mass Index in Mexicans.
[PMID 30822753] Effects of fat mass and obesity-associated (FTO) gene polymorphisms on binge eating in women with binge-eating disorder: The moderating influence of attachment style.
[PMID 31075924] Physical Activity Might Reduce the Adverse Impacts of the FTO Gene Variant rs3751812 on the Body Mass Index of Adults in Taiwan.