|| common in complete genomics
|?|| (A;A) (A;G) (G;G) ||28|
] Associated with Nicotine Dependence
as part of several haplotypes, based on a study of 1,000+ subjects including both African-Americans and European-Americans.
Interestingly, the risk allele varies between populations. Among African-Americans, the haplotype C-C-G of rs2491397-rs2184026-rs3750344 had a significant positive association with nicotine dependence. Among European-Americans, for rs1435252-rs3780422-rs2779562-rs3750344, the C-A-C-A haplotype was positively associated with nicotine dependence while the T-A-T-A haplotype was negatively associated.[PMID 15759211]
|Desc||GAMMA-AMINOBUTYRIC ACID B RECEPTOR 2; GABBR2|
] Association and interaction analyses of GABBR1 and GABBR2 with nicotine dependence in European- and African-American populations.