[PMID 19270442] Haplotype analysis of the engrailed-2 gene in young-onset Parkinson's disease
[PMID 15024396] Association of the homeobox transcription factor, ENGRAILED 2, 3, with autism spectrum disorder.
- "Flanking exonic SNPs (rs3735653 ...) did not display association."
[PMID 16252243] Support for the homeobox transcription factor gene ENGRAILED 2 as an autism spectrum disorder susceptibility locus. - no association found between rs3735653 and ASD
- "We have previously tested four SNPs (rs3735653, rs1861972, rs1861973, and rs2361689) that span the majority of the EN2 gene for association with ASD in 167 AGRE families (AGRE I data set) (Gharani et al. 2004). The rs3735653 and rs2361689 SNPs are located in exon 1 and exon 2, respectively, whereas the rs1861972 and rs1861973 SNPs are both located in the single intron. Significant association was observed for the common alleles of rs1861972 and rs1861973, both individually and as a haplotype (Gharani et al. 2004). In contrast, the two exonic SNPs were not associated with ASD."
[PMID 20050924] Family-based studies indicate association of Engrailed 2 gene with autism in an Indian population.