| Geno
|
Mag
|
Summary
|
| (C;C)
|
0
|
normal risk
|
| (C;T)
|
|
1.6x increased risk for heart disease
|
| (T;T)
|
2
|
Reduced risk for nasal polyps and chronic sinusitis
|
rs34210653 is a SNP in the ALOX15 gene, either encoding a threonine or a methionine at position 560 of the corresponding protein. This SNP is also known as T560M; the more common (C) allele encodes the threonine, and the rarer (T) allele encodes the methionine.
In mice, this protein appears to promote atherosclerosis, and mice completely lacking the entire gene are free of atherosclerosis. In contrast, rs34210653(T;T) humans, who effectively have a non-functioning variant, do not show a statistically significant decreased risk for coronary artery disease. And rs34210653(C;T) heterozygotes an increased risk of heart disease (adjusted odds ratio 1.62, p=0.02).[PMID 17959182
]
In 2019, a study of ~10,000 patients concluded that rs34210653(T) confers significant protection against nasal polyps (OR 0.32, CI: 0.26-0.39, p = 8.0 × 10e−27) and chronic rhinosinusitis (OR 0.64, CI: 0.55-75, p = 1.1 × 10e−8).[PMID 30643255]
[PMID 19046748] Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke.
[PMID 23906684] Genetic associations with coronary heart disease: Meta-analyses of 12 candidate genetic variants
]
