|(A;A)||0||later onset of BP|
|(A;G)||later onset of BP|
Although not associated with increased risk for developing bipolar disorder, amongst those with it, the (G) allele of this SNP has been reported to have a somewhat protective effect in that individuals who have a (G) allele develop bipolar disorder at a later age than those with the more common (A;A) genotypes. [PMID 15351432, PMID 14729229]
Also known as the -50T/C SNP from this GSK3-beta (GSK3B) gene.
may effect lithium treatment response - [PMID 17628506] C allele carriers showed considerably greater response with lithium treatment, with remissions of 56.25% after 4 weeks compared to 31% for T/T carriers
[PMID 19573950] GSK3beta polymorphisms, MAPT H1 haplotype and Parkinson's disease in a Greek cohort
[PMID 20055739] Role of glycogen synthase kinase 3 (GSK-3) in innate immune response of human immature dendritic cells to Aspergillus fumigatus
[PMID 21159074] SNCA, MAPT, and GSK3B in Parkinson disease: a gene-gene interaction study
[PMID 22119086] Gene-gene interaction of glycogen synthase kinase 3-? and serotonin transporter on human antidepressant response to sleep deprivation
[PMID 22815195] GSK3β reduces risk of sporadic Parkinson's disease in ethnic Chinese
[PMID 19154537] Epistasis between tau phosphorylation regulating genes (CDK5R1 and GSK-3beta) and Alzheimer's disease risk.
[PMID 20113358] Temporal lobe grey matter volume in schizophrenia is associated with a genetic polymorphism influencing glycogen synthase kinase 3-beta activity.
[PMID 21443865] Association analysis of GSK3B and MAPT polymorphisms with Alzheimer's disease in Han Chinese.
[PMID 21527318] GSK3beta genetic variability in patients with Multiple Sclerosis.
[PMID 23021822] Glycogen synthase kinase 3β gene polymorphisms may be associated with bipolar I disorder and the therapeutic response to lithium
[PMID 23440732] GSK-3β Polymorphism Discriminates Bipolar Disorder and Schizophrenia: A Systematic Meta-Analysis
[PMID 21130530] Role of tau kinases (CDK5R1 and GSK3B) in Parkinson's disease: a study from India
[PMID 22990942] Lithium and GSK3-beta promoter gene variants influence white matter microstructure in bipolar disorder.
[PMID 23030648] Possible association of the GSK3beta gene with the anxiety symptoms of major depressive disorder and P300 waveform.
[PMID 23628795] The association between glycogen synthase kinase 3 beta polymorphisms and Parkinson's disease susceptibility: a meta-analysis.
[PMID 24929537] Meta-analysis demonstrates lack of association of the GSK3B -50C/T polymorphism with risk of bipolar disorder
[PMID 24779391] MAPT rs242562 and GSK3B rs334558 are associated with Parkinson's Disease in central China
[PMID 28099358] The gender-specific association of rs334558 in GSK3β with major depressive disorder.