|| >1.1x risk of type-1 diabetes
|| 1.12x risk of type-1 diabetes
|?|| (A;A) (A;G) (G;G) ||28|
, one of several SNPs in the IL7R
gene, has been reported in a large study to be associated with type-1 diabetes
In an expanded follow-up study of >6,000 controls and 6,000 patients, the heterozygote odds ratio for this SNP was recalculated to be 1.12 (CI 1.05â€“1.19). [PMID 17554260]
|| [PMID 21297633]
|| Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
| Risk Allele
| Odds Ratio
|| 1.0700 [1.02-1.12]
[PMID 18563381] Study of the association between the CAPSL-IL7R locus and type 1 diabetes.
[PMID 19221116] Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS.
[PMID 19359276] Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes.
[PMID 19956108] Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3-q14.1.
|| Insufficiently evaluated pharmacogenetic