||HLA-DRB1*1501 carrier; higher multiple sclerosis risk
||3 to 6 fold higher risk for multiple sclerosis
rs3135391 is highly correlated with the HLA-DRB1*1501 allele. The risk allele (T), is associated with a 3 to 6 fold higher risk for developing multiple sclerosis, and is the most significantly associated risk factor for MS. [PMC2892470]
In one study, for example, the odds ratio was reported to be 3.04 (p < 1 x 10e-78).[PMID 20593013]
The HLA-DRB1*1501 allele has also been associated with other autoimmune diseases, such as systemic lupus erythematosis (SLE) (see) and possibly narcolepsy. The HLA-DRB1*1501 allele is fairly common; for example, it occurs in 15-30% of individuals of Northern European ancestry. [PMC2892470]
An interesting series of correlations have been woven together to suggest that a possible way to lower the risk of rs3135388(T) carriers developing multiple sclerosis would be to ensure sufficient vitamin D production, presumably through sunlight exposure, during as yet unknown critical periods in development. 10.1371/journal.pgen.1000369
[PMID 19143815] MHC fine mapping of human type 1 diabetes using the T1DGC data.
[PMID 19846760] Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases.
[PMC2892470] A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01.