||normal risk for infertility in Chinese men
||1.36 slightly higher risk for infertility in Chinese men
||>1.36 higher risk for infertility in Chinese men
rs3129878 is a SNP in the HLA gene region. It has been associated with slightly (~30%) higher risk for azoospermia (lack of sperm) and thus male infertility in both Chinese and Japanese men.[PMID 22541561][PMID 23934009]
[PMID 23934009] HLA-DPB1*04:01 allele is associated with non-obstructive azoospermia in Japanese patients
[PMID 19846760] Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases.
[PMID 22541561] A genome-wide association study reveals that variants within the HLA region are associated with risk for nonobstructive azoospermia.