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rs3024490

From SNPedia
Orientationminus
Stabilizedminus
Geno Mag Summary
(G;G) 0
Make rs3024490(G;T)
Make rs3024490(T;T)
ReferenceGRCh38 38.1/141
Chromosome1
Position206771966
GeneIL10
is asnp
is mentioned by
dbSNPrs3024490
dbSNP (old)rs3024490
ClinGenrs3024490
ebirs3024490
HLIrs3024490
Exacrs3024490
Gnomadrs3024490
Varsomers3024490
Maprs3024490
PheGenIrs3024490
Biobankrs3024490
1000 genomesrs3024490
hgdprs3024490
ensemblrs3024490
gopubmedrs3024490
geneviewrs3024490
scholarrs3024490
googlers3024490
pharmgkbrs3024490
gwascentralrs3024490
openSNPrs3024490
23andMers3024490
23andMe allrs3024490
SNP Nexus

SNPshotrs3024490
SNPdbers3024490
MSV3drs3024490
GWAS Ctlgrs3024490
GMAF0.4077
Max Magnitude0
? (G;G) (G;T) (T;T) 28
[PMID 20335604] Cytokine polymorphism in non-infectious uveitis.

According to a 2010 report, each A (minor) allele at rs3024490 in the IL10 gene increased the risk of Behçet's disease about 1.4 times in a Turkish population. [PMID 20622878OA-icon.png]


[PMID 19264973OA-icon.png] Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.


[PMID 19468064OA-icon.png] Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions. The aim of the study was to map SNP/gene associations with environmental pathogen-richness in relation to genomic variations across geographic human populations. This 2009 article found that "six risk alleles for inflammatory bowel (IBD) or celiac disease are significantly correlated with micropathogen richness. These data support the hygiene hypothesis for IBD and provide a large set of putative targets for susceptibility to helminth infections." (Abstract) Table I. identified rs3024490 among a list of 44 SNPs analyzed in relation to micro- and macro-pathogens. This SNP was not previously associated with IBD and celiac disease and was negatively associated with pathogen richness.


[PMID 19852851OA-icon.png] Asthma and genes encoding components of the vitamin D pathway.


[PMID 19907653OA-icon.png] Selection for genetic variation inducing pro-inflammatory responses under adverse environmental conditions in a Ghanaian population. This 2009 study identified a haplotype among Ghanaians consisting of minor alleles at four SNPs in the IL-10 gene: rs1800871, rs1800872, rs3024490 and rs1554286. This combination of risk alleles led to lower IL-10 expression and higher TNF gene expression, resulting in a pro-inflammatory response. The authors explain that in Ghana, "pro-inflammatory alleles rescue their carriers of excess mortality in adverse environmental conditions" such as drinking from boreholes, and thus minor alleles occur more frequently in African populations, but "in an affluent environment, the same pro-inflammatory response leads to increased mortality," and minor alleles occur much less frequently (i.e. in Caucasian populations).


[PMID 20041166OA-icon.png] Common genetic variation and the control of HIV-1 in humans.


[PMID 28268030] Influence of IL1B, IL6 and IL10 gene variants and plasma fatty acid interaction on metabolic syndrome risk in a cross-sectional population-based study.