|| in Japanese, possible delayed sleep phase condition
|| common in complete genomics
, also known as Ala129Thr or A129T (and also G619A), is a SNP in the aralkylamine N-acetyltransferase AANAT
gene. The AANAT
protein plays a unique role in vertebrate biology by controlling rhythmic production of melatonin in the pineal gland. Its activity increases 10- to 100-fold at night, leading to increased production and release of melatonin.
In a 2003 report about Japanese patients with a sleep disorder known as susceptibility to delayed sleep phase syndrome, patient genotypes had a higher frequency of the rs28936679(A) allele.[PMID 12736803]
A later report based on Brazilian (primarily Caucasian) patients including those with delayed sleep phase syndrome found no variation at this SNP.[PMID 17503170]