| Geno
|
Mag
|
Summary
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| (T;T)
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1
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Potential environmental trigger for autoimmune diseases
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A 2013 study of ~1,000+ Chinese patients with narcolepsy concluded that the common rs2854536(T) allele had a slight association with the condition. As stated in the article:
"Narcolepsy-hypocretin deficiency results from a highly specific autoimmune attack on hypocretin cells....
Recent studies have established antigen presentation by specific class II proteins encoded by (HLA DQB1*06:02 and DQA1*01:02) to the cognate T cell receptor as the main disease pathway, with a role for H1N1 influenza in the triggering process....
We also identified differences in HLA haplotype frequencies among cases with onset following the 2009 H1N1 influenza pandemic as compared to before the outbreak, with fewer HLA DQB1*06:02 homozygotes....
This may be the first demonstration of such an effect, and suggests that the study of changes in GWAS signals over time could help identify environmental factors in other autoimmune diseases."[PMID 24204295
]
| GWAS snp
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| PMID
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[PMID 24204295]
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| Trait
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Narcolepsy
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| Title
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Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic.
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| Risk Allele
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|
| P-val
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4E-8
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| Odds Ratio
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1.28 [1.18-1.41]
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]
