|| CYP3A5*2 homozygote; nonexpressor for CYP3A5
|| carrier of one CYP3A5*2 allele
|?|| (A;A) (A;C) (C;C) ||28|
, also known as 27289C>A, is a SNP in the CYP3A5
The rs28365083(A) allele defines the CYP3A5*2 variant, which is nonfunctional.
[PMID 17615053] Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1 and colorectal cancer risk.
[PMID 18547414] Genotyping panel for assessing response to cancer chemotherapy.
[PMID 19076156] Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa.
[PMID 20389299] Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism.