||topiramate may work to reduce heavy drinking best for this genotype
The rs2832407(C) allele has inconsistently been linked to alcoholism and its treatment. Nonetheless, a 2014 report based on 138 patients concludes that rs2832407(C;C) individuals show a greater decrease than non-carriers (of a rs2832407(C) allele) in the number of heavy drinking days per week when taking topiramate at a dose of 200 mg/daily.[PMID 24525690] A follow-up study done 3 and 6 months after treatment seemed to mostly confirm the topiramate benefit preferentially to rs2832407(C;C) individuals.[PMID 25581656]
[PMID 19320626] Association of Markers in the 3' Region of the GluR5 Kainate Receptor Subunit Gene to Alcohol Dependence.
[PMID 19331489] A preliminary pharmacogenetic investigation of adverse events from topiramate in heavy drinkers
[PMID 24525690] Topiramate Treatment for Heavy Drinkers: Moderation by a GRIK1 Polymorphism