|(G;G)||1||Duffy-negative, Fy(a-b-) phenotype; resistance to malaria;, increased odds of HIV infection upon exposure, but slowed disease progression if infected|
rs2814778 is within the DARC gene, which encodes the Duffy blood group antigen [PMID 7663520]. This SNP shows an almost perfectly fixed difference in frequency between Europeans and those with African ancestry. (One exception appears to be a certain population of Czech gypsies, and certain non-Ashkenazi Jewish populations.) Additionally the Namibian San samples of the CEPH-HGDP are, uncharacteristically for Africans, all AA homozygotes for this SNP.
[PMID 19180233] rs2814778(G;G) protect against Plasmodium vivax malaria and predicts of white blood cell and neutrophil count
23andMe blog discussion
|Title||Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women.|
|Odds Ratio||None None|
[PMID 22207676] The association between a Darc gene polymorphism and clinical outcomes in African Americans with acute lung injury
|Title||Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network.|
|Odds Ratio||1.3500 None|
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[PMID 21257350] DNA-based methods in the immunohematology reference laboratory.
|Disease||DUFFY BLOOD GROUP SYSTEM Plasmodium vivax White blood cell count quantitative trait locus 1|
|CLNDBN||DUFFY BLOOD GROUP SYSTEM, FY(a-b-) PHENOTYPE Plasmodium vivax, resistance to White blood cell count quantitative trait locus 1|
|CLNSRC||OMIM Allelic Variant dbRBC - Blood Group Antigen Gene Mutation Database|
|CLNACC||RCV000000006.4, RCV000000007.3, RCV000000008.3,|
[PMID 29596498] Analyses of genome wide association data, cytokines, and gene expression in African-Americans with benign ethnic neutropenia.