|(G;G)||2.5||1.5x~2.7x more likely to live to 100.|
|(G;T)||2||One copy of a longevity gene. Slightly increased lifespan.|
|(T;T)||2.5||Less likely to live to 100.|
|?||(G;G) (G;T) (T;T)||28|
A study of 5 genes in 3,741 Japanese men, some of whom lived significantly longer than average (centarians), concluded that the FOXO3 gene (also known as FOXO3A) harbors several SNPs linked to longevity, including this SNP, rs2802292, as well as rs2764264 and rs13217795.
The odds ratio for rs2802292(G;G) vs (T;T) carriers was 2.75 (p = 0.00009; adjusted p = 0.00135). It is not known yet if this correlation is specific to Japanese males.[PMID 18765803]
This is discussed extensively at geneticfuture as a longevity snp.
- (T) shorter lifespan
- (G) longer lifespan
Quoted from the geneticfuture article: "No-one should consider this association to be definitive until it's been replicated in independent cohorts. Secondly, the effects of this variant are likely to differ between groups. According to the HapMap database the frequency of the "die early" (T) version of the variant varies substantially between populations: it's around 76% in Japanese, slightly more common (81%) in Chinese, less common (58%) in Europeans, and quite rare (17%) in West Africans. Given that the Japanese have the highest life expectancy of any of these populations, this is a counter-intuitive result, which reinforces the fact that there are many genes and other factors influencing variation in longevity."
23andMe blog longevity rs2802288(A) increased the odds of living to 100 by 1.5x. rs2802288 is located very close to rs2802292 which was previously reported to have a similar effect.
A study of males from the Southern Italian Centenarian Study also replicated the association between rs2802288, a proxy of rs2802292, and longevity, with an odds ratio of 1.51 (CI: 1.15-1.98, p = 0.003).[PMID 19415983]
[PMID 21621268] Genetic variations in FOXO3A are associated with Bipolar Disorder without confering vulnerability for suicidal behavior
[PMID 19196970] Association of FOXO3A variation with human longevity confirmed in German centenarians.
[PMID 20881262] The FOXO3A rs2802292 G-allele associates with improved peripheral and hepatic insulin sensitivity and increased skeletal muscle-FOXO3A mRNA expression in twins.
[PMID 21115529] Genetics and genomics of human ageing.
[PMID 24350933] Association Between Genetic Variations In The Insulin/Insulin-Like Growth Factor (Igf-1) Signaling Pathway And Longevity: A Systematic Review And Meta-Analysis
[PMID 25208626] Characterization of the rs2802292 SNP identifies FOXO3A as a modifier locus predicting cancer risk in patients with PJS and PHTS hamartomatous polyposis syndromes
[PMID 27071935] The FoxO3 gene and cause-specific mortality
[PMID 31009445] Longevity-Associated Forkhead Box O3 (FOXO3) Single Nucleotide Polymorphisms are Associated with Type 2 Diabetes Mellitus in Chinese Elderly Women.
[PMID 32364002] Gene-Environment Interaction of <i>FOXO</i> and Residential Greenness on Mortality among Older Adults.
[PMID 33507936] The correlation of salivary telomere length and single nucleotide polymorphisms of the ADIPOQ, SIRT1 and FOXO3A genes with lifestyle-related diseases in a Japanese population.