|(G;G)||2.5||1.5x~2.7x more likely to live to 100.|
|(G;T)||2||One copy of a longevity gene. Slightly increased lifespan.|
|(T;T)||2.5||Less likely to live to 100.|
A study of 5 genes in 3,741 Japanese men, some of whom lived significantly longer than average (centarians), concluded that the FOXO3 gene (also known as FOXO3A) harbors several SNPs linked to longevity, including this SNP, rs2802292, as well as rs2764264 and rs13217795.
- (T) shorter lifespan
- (G) longer lifespan
Quoted from the geneticfuture article: "No-one should consider this association to be definitive until it's been replicated in independent cohorts. Secondly, the effects of this variant are likely to differ between groups. According to the HapMap database the frequency of the "die early" (T) version of the variant varies substantially between populations: it's around 76% in Japanese, slightly more common (81%) in Chinese, less common (58%) in Europeans, and quite rare (17%) in West Africans. Given that the Japanese have the highest life expectancy of any of these populations, this is a counter-intuitive result, which reinforces the fact that there are many genes and other factors influencing variation in longevity."
A study of males from the Southern Italian Centenarian Study also replicated the association between rs2802288, a proxy of rs2802292, and longevity, with an odds ratio of 1.51 (CI: 1.15-1.98, p = 0.003).[PMID 19415983]
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