|?|| (A;A) (A;T) (T;T) ||28|
This SNP in the GABRA2
gene has been linked to Alcoholism
The strongest association for this SNP is seen when it is a member of a haplotype consisting of the rs279871(A) + rs279845(T) + rs279836(A) alleles [PMID 15024690].
|Desc||GAMMA-AMINOBUTYRIC ACID RECEPTOR, ALPHA-2; GABRA2|
] GABRA2 markers moderate the subjective effects of alcohol
[PMID 18634760] Uncovering genes for cognitive (dys)function and predisposition for alcoholism spectrum disorders: a review of human brain oscillations as effective endophenotypes.
[PMID 18727688] The role of GABRA2 in alcohol dependence, smoking, and illicit drug use in an Australian population sample.
[PMID 19487630] Role of GABRA2 in trajectories of externalizing behavior across development and evidence of moderation by parental monitoring.
[PMID 20133874] Cocaine effects on mouse incentive-learning and human addiction are linked to alpha2 subunit-containing GABAA receptors.
[PMID 22555154] Gamma-aminobutyric acid A receptor, alpha-2 (GABRA2) variants as individual markers for alcoholism: a meta-analysis.