|(C;G)||1.8||0.73x decreased risk for colorectal cancer|
|(G;G)||2||0.73x decreased risk for colorectal cancer|
Two case-control studies including colorectal cancer patients and controls were conducted; the first case involving 441 patients and 658 controls, all of Ashkenazi Jewish ancestry, and the second including 199 patients and 199 matched (sex, age and ethnicity) controls.
rs266729(G) showed decreased colorectal cancer risk in both studies; in the first, with an odds ratio of 0.72 (CI:0.55-0.95) and in the second, with an odds ratio of 0.52 (CI: 0.34-0.78). Combining the two studies led to an overall decreased colorectal cancer odds ratio of 0.73 (CI: 0.53-0.99) for this allele.
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[PMID 19074982] Functional characterization of promoter variants of the adiponectin gene complemented by epidemiological data.
[PMID 19238139] ADIPOQ polymorphisms, monounsaturated fatty acids, and obesity risk: the GOLDN study.
[PMID 19324915] Association between the adiponectin promoter rs266729 gene variant and oxidative stress in patients with diabetes mellitus.
[PMID 19360113] The Role of the PGC1alpha Gly482Ser Polymorphism in Weight Gain due to Intensive Diabetes Therapy.
[PMID 19593725] Association of maternally inherited GNAS alleles with African-American male birth weight.
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[PMID 20032495] Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance.
[PMID 20114006] SOX2 has gender-specific genetic effects on diabetic nephropathy in samples from patients with type 1 diabetes mellitus in the GoKinD study.
[PMID 20201642] Associations of polymorphisms in adiponectin and leptin genes with men's longevity.
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[PMID 20554072] Gestational diabetes mellitus screening based on the gene chip technique.
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[PMID 20667095] Effects of MCF2L2, ADIPOQ and SOX2 genetic polymorphisms on the development of nephropathy in type 1 Diabetes Mellitus.
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[PMID 21073447] Lack of association between ADIPOQ rs266729 and ADIPOQ rs1501299 polymorphisms and cardiovascular disease in rheumatoid arthritis patients.
[PMID 21219602] Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study.
[PMID 21474811] Adiponectin level as a consequence of genetic variation, but not leptin level or leptin: adiponectin ratio, is a risk factor for carotid intima-media thickness.
[PMID 21623778] Adiponectin in chronic heart failure: influence of diabetes and genetic variants.
[PMID 21638131] Associations between single-nucleotide polymorphisms (+45T>G, +276G>T, -11377C>G, -11391G>A) of adiponectin gene and type 2 diabetes mellitus: a systematic review and meta-analysis.
[PMID 22023374] Application of back propagation artificial neural network on genetic variants in adiponectin ADIPOQ, peroxisome proliferator-activated receptor-gamma, and retinoid X receptor-alpha genes and type 2 diabetes risk in a Chinese Han population.
[PMID 22070425] Profile of inflammatory mediators in gestational diabetes mellitus: phenotype and genotype.
[PMID 22386722] Association of ADIPOQ gene polymorphisms and coronary artery disease risk: a meta-analysis based on 12 465 subjects.
[PMID 23041553] Genetic association of adipnectin with type 2 diabetes in Jordanian Arab population
[PMID 23143890] Adiponectin (ADIPOQ) rs2241766 G/T polymorphism is associated with risk of cancer: evidence from a meta-analysis
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[PMID 23803590] Polymorphisms of the adiponectin gene in gestational hypertension and pre-eclampsia
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[PMID 23144319] Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study.
[PMID 23144325] P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy.
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[PMID 25038177] Genetic variations of the ADIPOQgene and risk of prostate cancer in Chinese Han men
[PMID 25074391] Correlation of serum adiponectin and adiponectin gene polymorphism with metabolic syndrome in Chinese adolescents
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[PMID 27159547] Adipokine Gene Single-Nucleotide Polymorphisms in Portuguese Obese Adolescents: Associations with Plasma Concentrations of Adiponectin, Resistin, IL-6, IL-1β, and TNF-α.
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