| Geno
|
Mag
|
Summary
|
| (A;G)
|
1.1
|
1.1x higher risk for migraines
|
| (G;G)
|
1.2
|
1.2x higher risk for migraines
|
rs2651899 is a SNP on ch 1p36.32 in the PRDM16 gene.
A large GWAS study of over 5,000 patients with migraines and a meta-analysis concluded that this SNP was one of three influencing the condition, albeit with only slight risk increases on its own. The odds ratio for the slightly rarer rs2651899(G) allele was 1.11 (CI: 1.07 - 1.15, p = 3.8 x 10e-9).10.1038/ng.856
A 2013 study published by the American Headache Society reports significant influence of rs1835740, LRP1 rs11172113 and PRDM16 rs2651899 polymorphisms on migraine susceptibility in the Northern Indian population. [PMID 24266335]
| GWAS snp
|
| PMID
|
[PMID 21666692 ]
|
| Trait
|
|
| Title
|
Genome-wide association study reveals three susceptibility loci for common migraine in the general population.
|
| Risk Allele
|
C
|
| P-val
|
4E-9
|
| Odds Ratio
|
1.1100 [1.07-1.15]
|
[PMID 22072275] Genetics of migraine in the age of genome-wide association studies
[PMID 24021092] PRDM16 rs2651899 Variant Is a Risk Factor for Chinese Common Migraine Patients
[PMID 23294458] Replication and meta-analysis of common variants identifies a genome-wide significant locus in migraine
| GWAS snp
|
| PMID
|
[PMID 23793025]
|
| Trait
|
Migraine
|
| Title
|
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
|
| Risk Allele
|
C
|
| P-val
|
4E-14
|
| Odds Ratio
|
1.09 [1.07-1.11]
|
[PMID 24266335] Genome-wide-associated variants in migraine susceptibility: a replication study from North India.
[PMID 24674449] A replication study of GWAS findings in migraine identifies association in a Swedish case-control sample
[PMID 30382894] Implications for the migraine SNP rs1835740 in a Swedish cluster headache population.
[PMID 30635810] rs2651899 variant is associated with risk for migraine without aura from North Indian population.
]
