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rs2359612

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 common in clinvar
Make rs2359612(A;G)
Make rs2359612(G;G)
ReferenceGRCh38 38.1/141
Chromosome16
Position31092475
GeneVKORC1
is asnp
is mentioned by
dbSNPrs2359612
dbSNP (old)rs2359612
ClinGenrs2359612
ebirs2359612
HLIrs2359612
Exacrs2359612
Gnomadrs2359612
Varsomers2359612
Maprs2359612
PheGenIrs2359612
Biobankrs2359612
1000 genomesrs2359612
hgdprs2359612
ensemblrs2359612
gopubmedrs2359612
geneviewrs2359612
scholarrs2359612
googlers2359612
pharmgkbrs2359612
gwascentralrs2359612
openSNPrs2359612
23andMers2359612
23andMe allrs2359612
SNP Nexus

SNPshotrs2359612
SNPdbers2359612
MSV3drs2359612
GWAS Ctlgrs2359612
GMAF0.4986
Max Magnitude0
? (A;A) (A;G) (G;G) 28
[PMID 22321278] [Impact of CYP2C9 and VKORC1 polymorphism on warfarin response during initiation of therapy]


[PMID 17048007OA-icon.png] Association of warfarin dose with genes involved in its action and metabolism.


[PMID 17549303] Functional promoter polymorphism in the VKORC1 gene is no major genetic determinant for coronary heart disease in Northern Germans.


[PMID 18252229OA-icon.png] Warfarin pharmacogenetics: CYP2C9 and VKORC1 genotypes predict different sensitivity and resistance frequencies in the Ashkenazi and Sephardi Jewish populations.


[PMID 18466099OA-icon.png] Influence of CYP2C9 and VKORC1 on warfarin dose, anticoagulation attainment and maintenance among European-Americans and African-Americans.


[PMID 18523153OA-icon.png] Regulatory polymorphism in vitamin K epoxide reductase complex subunit 1 (VKORC1) affects gene expression and warfarin dose requirement.


[PMID 18559094OA-icon.png] Warfarin dose and INR related to genotypes of CYP2C9 and VKORC1 in patients with myocardial infarction.


[PMID 18574025OA-icon.png] The largest prospective warfarin-treated cohort supports genetic forecasting.


[PMID 18752379OA-icon.png] Warfarin pharmacogenetics.


[PMID 18841283] Single nucleotide polymorphisms in the VKORC1 gene and the risk of stroke in the Southern German population.


[PMID 18855533OA-icon.png] VKORC1 polymorphisms, haplotypes and haplotype groups on warfarin dose among African-Americans and European-Americans.


[PMID 19074728OA-icon.png] Relative contribution of CYP2C9 and VKORC1 genotypes and early INR response to the prediction of warfarin sensitivity during initiation of therapy.


[PMID 19228618OA-icon.png] Estimation of the warfarin dose with clinical and pharmacogenetic data.


[PMID 19300499OA-icon.png] A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose.


[PMID 19738376] Pharmacogenetic testing for guiding de novo phenprocoumon therapy in stroke patients.


[PMID 19955245OA-icon.png] Warfarin sensitivity genotyping: a review of the literature and summary of patient experience.


[PMID 22178823] [Distribution of variant alleles association with warfarin pharmacokinetics and pharmacodynamics in the Han population in China].


GET Evidence
rs2359612
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.614754
summary



[PMID 26040031] [Association of allelic polymorphisms of genes matrix Gla-protein system with ischemic atherothrombotic stroke]


ClinVar
Risk rs2359612(G;G)
Alt rs2359612(G;G)
Reference Rs2359612(A;A)
Significance Drug-response
Disease warfarin response - Dosage
Variation info
Gene VKORC1
CLNDBN warfarin response - Dosage
Reversed 0
HGVS NC_000016.9:g.31103796A>G
CLNSRC PharmGKB Clinical Annotation
CLNACC RCV000211406.1,



[PMID 27889279] Vitamin K epoxide reductase expression and prostate cancer risk.