||common in complete genomics
rs2304016 (IVS7-32A>G) is a SNP within the SCN2A (sodium channel, voltage-gated, type II, alpha subunit).
[PMID 18784617] among 471 Chinese epilepsy patients (of which 272 were drug responsive and 199 drug resistant), A-allele carriers associated with resistance to anti-epileptic drugs (OR 2.1, 95% CI 1.2-3.7, p=0.007), haplotypes containing A-alleles were also associated w/ drug resistance
[PMID 22569204] PharmGKB summary: phenytoin pathway.
[PMID 26189305] ABCB1, ABCC2, SCN1A, SCN2A, GABRA1 gene polymorphisms and drug resistant epilepsy in the Chinese Han population
[PMID 30693367] SCN1A and SCN2A polymorphisms are associated with response to valproic acid in Chinese epilepsy patients.