|| common in clinvar
showed as strong an association with increased susceptibility to neovascular age related macular degeneration
as the haplotypes containing rs10490924
[PMID 18207215] rs2293870 and rs11200638 are among the most significantly associated HTRA1 SNPs with age related macular degeneration.
] Comprehensive Analysis of Complement Factor H and LOC387715/ARMS2/HTRA1 Variants with Respect to Phenotype in Advanced Age-related Macular Degeneration
[PMID 18316707] HTRA1 variants in exudative age-related macular degeneration and interactions with smoking and CFH.
[PMID 19026761] Molecular pathology of age-related macular degeneration.
[PMID 20140183] Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration.
[PMID 23644223] Variants at chromosome 10q26 locus and the expression of HTRA1 in the retina
[PMID 26310622] Synonymous variants in HTRA1 implicated in AMD susceptibility impair its capacity to regulate TGF-β signaling